Peptide Titration Calculator
Build a week-by-week dose escalation schedule with exact calendar dates. Enter your start and target dose, set the pace, and get a personalized timeline.
What is peptide titration?
Titration means starting at a low dose and incrementally increasing it over weeks until you reach the therapeutic target. The purpose is straightforward: it lets your body adapt gradually so side effects stay manageable.
Klarovel protocols use a 3-phase model: a ramp-up period at reduced dose, the main phase at full therapeutic dose, and a taper before the off-cycle. GLP-1 peptides like semaglutide and tirzepatide use a multi-step escalation instead, climbing through defined dose levels over 16-24 weeks.
The presets in this calculator match the exact protocols used in Klarovel-generated protocols. The custom builder lets you plan the same 3-phase structure for any peptide.
Standard titration protocols
Reference schedules for common peptides. Each follows published dosing guidelines. Expand any protocol to see the phase breakdown and practical notes.
Worked titration examples
Four standard escalation patterns the calculator can build for you, with the reasoning behind each step length.
Semaglutide 2.4 mg weekly target
Label-driven 16 week escalation: 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, then 2.4 mg from week 17 onward. Each step is held for four weeks so gastrointestinal tolerance can stabilise before the next escalation. Real-world adjustment: holding an extra 2 to 4 weeks at a step where nausea is intrusive is associated with much better long-term adherence than pushing through.
Tirzepatide 15 mg weekly target
Six-step ladder per SURMOUNT-1: 2.5 mg weeks 1 to 4, 5 mg weeks 5 to 8, 7.5 mg weeks 9 to 12, 10 mg weeks 13 to 16, 12.5 mg weeks 17 to 20, 15 mg from week 21 onward. Many patients stop at 5 mg or 10 mg if response is sufficient and side effects are notable. The correct target is the lowest dose producing the desired result with tolerable side effects, not the maximum.
GH-axis stack (CJC-1295 + ipamorelin) 8 week cycle
3-phase structure: weeks 1 to 2 ramp at 50% of standard dose (e.g., 100 mcg CJC + 100 mcg ipamorelin), weeks 3 to 6 full dose (200 mcg each), weeks 7 to 8 taper back to 50% to ease the off-cycle transition. The 4 week off period restores GHRH and ghrelin receptor sensitivity before the next cycle starts.
MK-677 8 week cycle (capped per F-02 audit)
Start at 12.5 mg nightly for two weeks (the lower starting dose limits initial water retention and grogginess on waking). Hold at 25 mg from weeks 3 to 6 if tolerated and IGF-1 stays under the age-adjusted ceiling. Taper back to 12.5 mg in weeks 7 to 8, then off for at least 4 weeks. Klarovel caps MK-677 at 8 weeks total because the BMD and CHF safety signals scale with cycle length, not just absolute dose.
Common titration mistakes
Four patterns that most often turn a clean titration into an abandoned cycle.
Jumping a titration step because symptoms are mild
GI tolerance and dose-response are not the same axis. Mild nausea at 0.5 mg semaglutide does not mean 1.0 mg will also be tolerable; it means your body has not yet adapted to the current dose, and stepping up early often triggers severe nausea that aborts the protocol. Hold a step the full four weeks even when it feels easy.
Restarting at the previous top dose after a pause
If you miss two or more weekly doses, restart at the dose level immediately below where you stopped, not at your previous top. Receptor desensitisation reverses fast enough that resuming at full dose often triggers a fresh nausea peak. The exception is single missed doses within 5 days, where you take the dose immediately and continue the schedule.
Confusing titration with cycling
Titration is the ramp-up to therapeutic dose, run once at the start. Cycling is the on-period followed by an off-period, repeated. GLP-1 agonists (semaglutide, tirzepatide, retatrutide) titrate but do not cycle, because cycling them off causes weight regain. GH-axis peptides cycle but the titration is usually a single 1 to 2 week ramp at the cycle start.
Using the same titration pace across different peptides
Semaglutide tolerates 4 weeks per step because gastric emptying adaptation is the limiting factor. Tirzepatide uses the same pace for the same reason. GH-axis peptides need only a 1 to 2 week ramp because the rate-limiting adaptation is pituitary feedback sensitivity, which adjusts faster. Copying a GLP-1 titration pace onto a GH-axis stack delays the protocol unnecessarily.
Managing side effects during escalation
Mild nausea at each dose increase is expected and usually fades within 1-2 weeks. These strategies help minimize discomfort during the transition.
Stay hydrated
64 oz of water minimum daily. Dehydration amplifies nausea and constipation, both common during dose increases.
Smaller meals, more often
GLP-1 peptides slow gastric emptying. Large meals sit longer and feel worse. Smaller portions spread across the day work better.
Avoid high-fat foods during ramps
Fatty foods take the longest to digest. During the first 1-2 weeks at each new dose, lean protein and simple carbs are easier on the stomach.
Inject in the evening
Peak side effects hit a few hours after injection. Evening dosing means the worst passes while you sleep.
Rotate injection sites
Alternate between abdomen, thigh, and upper arm. Repeated injections in the same spot can cause local irritation and lipodystrophy.
Know when to extend a phase
If nausea has not improved after 2 weeks at a dose, stay at that level for another 1-2 weeks before moving up. This is normal, not a failure.
When to contact a provider. Persistent vomiting beyond 3 days, severe abdominal pain, inability to keep fluids down, or signs of allergic reaction (rash, swelling, difficulty breathing) warrant immediate medical attention. These are not normal titration side effects.
Common questions
Dose escalation timing, safety, and how the schedule works.
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