How many drops of Semax do I take?

It depends on the strength of your solution and how much one drop holds. Percent strength is grams per 100 ml, so a 0.1% solution is 1 mg/ml; at a typical 0.05 ml drop that is 50 mcg per drop, and a 300 mcg dose is six drops, three per nostril. A 1% solution is ten times stronger and the same dose stops dividing evenly. Enter both in the calculator.

When should Semax be taken?

The engine catalog specifies morning or early afternoon and notes that late-day use may affect sleep. The administration section on this page carries the catalog note verbatim.

Why does the dose range widen so much with experience?

Because the engine dose table carries a much wider envelope for Semax at the higher experience levels than at the lower ones. The table on this page shows every level side by side so the shape of that ramp is visible rather than collapsed into one number.

Why do I see a lower maximum quoted elsewhere?

Because the two Klarovel sources differ and the page shows both. The engine dose table permits an experienced user considerably more than the older research row does, and the engine dose table is the one that binds in production. The page names which figure binds instead of publishing whichever is more convenient.

Does body weight change the Semax dose?

No. The engine catalog does not flag Semax weight sensitive and the dose calculator applies no generic weight scaling, so the tool leaves the target alone.

Does Semax need cycling?

The engine catalog carries an on-period and an off-period for it, both shown on this page and used by the supplies plan. Its on-period is the shortest of this set of pages.

Where do the numbers on this page come from?

The dose table, the ceilings and the frequency come from the Klarovel engine's own dose table, the same rows the protocol generator doses from. Route, timing, cycling and weight sensitivity come from the engine catalog. Nothing on this page is a number someone typed into an article, which is the failure mode most dosing pages share.

Is this calculator free?

Yes. No account, no paywall, no usage limit. The protocol engine behind it is a separate product, but the calculator is open.

Does Klarovel sell this peptide?

No. Klarovel is the protocol layer: a questionnaire, a deterministic rules engine and a generated protocol. Any product is fulfilled by partner suppliers, not by Klarovel.

Is this medical advice?

No. It is arithmetic over published dose data, presented as a reference. It is not a prescription and not a recommendation to use any compound. Discuss peptide use with a qualified clinician.

Semax dosage calculator

Semax is dosed in micrograms, timed to the morning, and given intranasally: the engine dose table records that route on all five experience levels. Enter your solution strength and drop volume for drops per dose.

Below the calculator: the dose envelope per experience level, the cycle length, the health conditions that change the answer, and the references. Every dose figure is read from the Klarovel engine dose table, never authored by hand. There is no reconstitution chart here because there is nothing to reconstitute: Semax is supplied as a solution and measured in drops.

What strength is your Semax solution?

Read it off the bottle. Percent here is % w/v, meaning grams per 100 mL, so 0.1% is 1 mg/mL.

How much does one drop hold?

Droppers vary, which is why this is a setting rather than an assumption. 0.05 ml is the common default. If your bottle states a volume per drop, use that.

Experience level

Selects the dose row the engine would use. The target below is read from that row, not chosen here.

Bottle size

Target dose, beginner row

500 mcg

once or twice daily, intranasal

Draw

10 drops

5 in each nostril

50 mcg per drop at 0.1% and 0.05 ml per drop, across 2 nostrils.

Doses per bottle

3 ml at 1 mg/ml, whole doses only.

Target doses come from the engine dose table. Solution strength and drop volume are yours: this page does the arithmetic, it does not decide the dose.

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About Semax

Semax is a synthetic analogue of the ACTH(4-10) fragment with a proline-glycine-proline tail. The published work centres on neurotrophin signalling: several studies report effects on BDNF and its receptor, and there is a body of Russian-language clinical work in ischaemic stroke.

It is timed to the morning or early afternoon in the catalog, because later administration can affect sleep. That is a scheduling constraint rather than a preference, and it is why the frequency and timing columns matter as much as the dose.

The dose is in micrograms. The engine dose table's upper bound for an experienced user sits well above the older research row's ceiling, and this page shows both figures and names which one binds.

Administration and cycling

Administration and cycling reference
Route	intranasal
Timing	Morning, fasted
Catalog frequency	1-2x daily
Cycle	4 weeks on, 4 weeks off
Taper before the off period	Not specified
Loading phase	None
Weight sensitive	No

Catalog note: Supplied as a 0.1% or 1% intranasal solution in a dropper bottle. Administer in the morning or early afternoon; avoid late-day use as it may affect sleep. Dose figures come from the engine dose table, not from this note.

Every row above is read from PEPTIDE_CATALOG, the engine catalog, and the note is quoted verbatim rather than paraphrased.

Two ceilings, and which one binds

Klarovel holds two upper bounds for Semax in two different places, and they do not agree. The engine dose table puts the highest ceiling at 3000 mcg across the experience levels. The older research row carries 300 mcg.

The engine dose table is the one that binds. The dose guard that caps generated protocols reads its ceilings from that table and falls back to the research row only where no dose row exists, because a guard that fights the engine trims legitimately curated doses and trains everyone to ignore its warnings.

Both figures are printed here rather than one, so a reader who finds the lower number elsewhere can see that both exist and which one the software actually uses.

When this would not be recommended for you

A public page cannot know your health data, so it cannot tell you whether a compound is appropriate. What it can do is list the conditions the engine's contraindication matrix associates with this compound, and what the engine does about each. In a generated protocol these resolve automatically and the reason is shown alongside the exclusion.

Health conditions and the engine's action
Condition	Engine action	Reason
Mental health	Monitored	Cognitive peptides (Semax, Selank) affect neurotransmitter systems. Inform treating physician with mental health conditions.

Conditions, severities and reasons read verbatim from CONTRAINDICATION_RULES, the engine's contraindication matrix. This is not the full set of things worth raising with a clinician; it is the set the engine acts on.

Questions

How many drops of Semax do I take?: It depends on the strength of your solution and how much one drop holds. Percent strength is grams per 100 ml, so a 0.1% solution is 1 mg/ml; at a typical 0.05 ml drop that is 50 mcg per drop, and a 300 mcg dose is six drops, three per nostril. A 1% solution is ten times stronger and the same dose stops dividing evenly. Enter both in the calculator.
When should Semax be taken?: The engine catalog specifies morning or early afternoon and notes that late-day use may affect sleep. The administration section on this page carries the catalog note verbatim.
Why does the dose range widen so much with experience?: Because the engine dose table carries a much wider envelope for Semax at the higher experience levels than at the lower ones. The table on this page shows every level side by side so the shape of that ramp is visible rather than collapsed into one number.
Why do I see a lower maximum quoted elsewhere?: Because the two Klarovel sources differ and the page shows both. The engine dose table permits an experienced user considerably more than the older research row does, and the engine dose table is the one that binds in production. The page names which figure binds instead of publishing whichever is more convenient.
Does body weight change the Semax dose?: No. The engine catalog does not flag Semax weight sensitive and the dose calculator applies no generic weight scaling, so the tool leaves the target alone.
Does Semax need cycling?: The engine catalog carries an on-period and an off-period for it, both shown on this page and used by the supplies plan. Its on-period is the shortest of this set of pages.
When is Semax not appropriate?: The conditions table on this page lists what the engine's contraindication matrix associates with this compound, with the engine's own reason and the severity.
Where do the numbers on this page come from?: The dose table, the ceilings and the frequency come from the Klarovel engine's own dose table, the same rows the protocol generator doses from. Route, timing, cycling and weight sensitivity come from the engine catalog. Nothing on this page is a number someone typed into an article, which is the failure mode most dosing pages share.
Is this calculator free?: Yes. No account, no paywall, no usage limit. The protocol engine behind it is a separate product, but the calculator is open.
Does Klarovel sell this peptide?: No. Klarovel is the protocol layer: a questionnaire, a deterministic rules engine and a generated protocol. Any product is fulfilled by partner suppliers, not by Klarovel.
Is this medical advice?: No. It is arithmetic over published dose data, presented as a reference. It is not a prescription and not a recommendation to use any compound. Discuss peptide use with a qualified clinician.

Other peptide calculators

References

These papers cover Semax mechanism, its effects on neurotrophin and receptor expression, the transcriptional work in ischaemia models, and the clinical literature in stroke.

The dose figures on this page are not sourced from these papers. They are read from the Klarovel engine's own dose table, which is cited inline wherever a number appears. These references cover mechanism, pharmacology and clinical context.

18 references, every identifier resolved against NCBI on 2026-08-03. Per peptide, a relevance-sorted esearch was run and every returned id was resolved through esummary. Any id esummary could not resolve was dropped, and any record carrying the 'Retracted Publication' pubtype was dropped. Titles, journals, years and first authors below are the values esummary returned, not authored text. One retracted record was dropped: PMID 37696839 (thymosin beta 4 query). Regenerated 2026-08-03 for cjc1295_no_dac, ipamorelin, pt141, retatrutide, aod9604 and sermorelin using the same esearch + esummary procedure; no record was added whose esummary payload lacked a title, journal or first author.

1.Dolotov OV et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem 2006. PMID 16635254
2.Dolotov OV et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res 2006. PMID 16996037
3.Dmitrieva VG et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol 2010. PMID 19633950 PMC11498467
4.Eremin KO et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res 2005. PMID 16362768
5.Medvedeva EV et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics 2014. PMID 24661604 PMC3987924
6.Medvedeva EV et al. Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats. Mol Genet Genomics 2017. PMID 28255762
7.Filippenkov IB et al. Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats. Genes (Basel) 2020. PMID 32580520 PMC7350263
8.Gusev EI et al. [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova 2018. PMID 29798983
9.Liu R et al. Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol 2025. PMID 40692165
10.Radchenko AI et al. The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease. Acta Naturae 2025. PMID 41479572 PMC12755871
11.Panikratova YR et al. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci 2020. PMID 32342318
12.Lebedeva IS et al. Effects of Semax on the Default Mode Network of the Brain. Bull Exp Biol Med 2018. PMID 30225715
13.Manchenko DM et al. [Nootropic and analgesic effects of Semax following different routes of administration]. Ross Fiziol Zh Im I M Sechenova 2010. PMID 21268834
14.Glazova NY et al. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides 2021. PMID 33418449
15.Sudarkina OY et al. Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. Int J Mol Sci 2021. PMID 34201112 PMC8226508
16.Sciacca MFM et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci 2022. PMID 35080861 PMC8855339
17.Dergunova LV et al. [The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain]. Mol Biol (Mosk) 2021. PMID 34097675
18.Agapova TY et al. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10. Neurosci Lett 2007. PMID 17353092

Beyond the arithmetic

Your health data, your protocol.

A calculator converts a dose into syringe units. The Klarovel engine decides the dose: it reads your health data, resolves contraindications, sets the envelope by experience level, removes incompatible pairs and builds the cycling and monitoring schedule. Blood work is optional and sharpens the result. It is never required.