How every protocol is checked
Last updated: 25 September 2026.
Every Klarovel protocol is built and checked by a deterministic safety engine before it reaches you. The engine applies the same rules to every protocol and gives the same answer for the same inputs. The checks below do not just warn: depending on the check, a peptide is removed, a dose is corrected, or the protocol is not delivered.
Before a word is written
The engine works through your health profile first. Nothing is written until these checks have run.
- Health conditions. 49 contraindication rules across 18 conditions and circumstances, including cancer history, kidney and liver disease, heart conditions and thyroid disease. Each rule blocks a peptide, flags it for caution, adds monitoring or reduces the dose. Pregnancy, breastfeeding or planning a pregnancy blocks every peptide.
- Medications. Your medications, including what you type in free text, are matched to drug classes and checked against interaction rules across 11 medication classes.
- Blood work, if you have it. Blood work is optional. When you add it, 46 thresholds across 17 biomarkers can block a peptide, flag it, or adjust its dose limits. An IGF-1 level above the healthy range for your age and sex blocks the growth-hormone peptides.
- Selection. Only peptides that pass the checks above can be chosen, and the number is capped by your experience: two to four.
- Combinations. 11 pairs of peptides are never combined, and known combinations get dose adjustments.
- Schedule. The engine sets cycling (on and off weeks), titration and a monitoring plan. GLP-1 medications follow the dose escalation on their FDA labels. It also tells you which tests would sharpen your next cycle.
After the protocol is written
The written protocol is checked against the engine's decisions before it is saved.
- Dose limits. Every dose is checked against a curated dose band. A dose above the maximum is capped; a dose below the starting dose is raised to it. From age 65, doses are capped at 75% of the standard dose (never below the starting dose). GLP-1 medications keep their label titration.
- Consistency. The same peptide must carry the same dose in every section, nothing may be dosed during an off-cycle week, and the cycling schedule is generated by the engine rather than written freehand. Doses per vial and vials needed are calculated, not estimated.
- Only approved peptides. Anything the engine blocked or did not select is removed, wherever it appears in the protocol. For a first protocol, a peptide without an enforceable dose limit is removed entirely.
- No invented numbers. If you did not provide blood work, biomarker values are not allowed into the report.
- Mixing guidance. If you told us you need help with reconstitution and the guide is missing, the protocol is not delivered.
Renewals
When you renew, the engine runs again with your results from the previous cycle, and every check above runs the same way. One difference: a peptide you have already run a cycle on is not dropped for lacking a dose limit; its dose stays bounded by the curated band where one exists. A pregnancy reported at renewal stops the renewal.
Where the rules come from
The rules draw on FDA labels, peer-reviewed research and Klarovel's curated dose tables. They live in code, and changes to them run against the engine's automated tests before they reach anyone's protocol. See the regulatory tracker for where each peptide stands with the FDA.
What this is not
These checks are automated. A protocol is not reviewed by a clinician before it reaches you, and it is not a prescription. Klarovel does not prescribe, and the engine is not a clinician. Talk to your own clinician before you start, change or stop anything, especially if you have a medical condition or take other medication. Our disclosures set out the full position.